Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

The PARK2 gene is mutated in 50% of autosomal recessive juvenile parkinsonism (ARJP) cases. It encodes parkin, an E3 ubiquitin ligase of the RBR family. Parkin exists in an autoinhibited state that is activated by phosphorylation of its N-terminal ubiquitin-like (Ubl) domain and binding of phosphoub...

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Publicado en:EMBO J
Main Authors: Kumar, Atul, Aguirre, Jacob D, Condos, Tara EC, Martinez-Torres, R Julio, Chaugule, Viduth K, Toth, Rachel, Sundaramoorthy, Ramasubramanian, Mercier, Pascal, Knebel, Axel, Spratt, Donald E, Barber, Kathryn R, Shaw, Gary S, Walden, Helen
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley & Sons, Ltd 2015
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609183/
https://ncbi.nlm.nih.gov/pubmed/26254304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201592337
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