Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation

The E3 ligase parkin ubiquitinates outer mitochondrial membrane proteins during oxidative stress and is linked to early‐onset Parkinson's disease. Parkin is autoinhibited but is activated by the kinase PINK1 that phosphorylates ubiquitin leading to parkin recruitment, and stimulates phosphoryla...

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Veröffentlicht in:EMBO J
Hauptverfasser: Condos, Tara EC, Dunkerley, Karen M, Freeman, E Aisha, Barber, Kathryn R, Aguirre, Jacob D, Chaugule, Viduth K, Xiao, Yiming, Konermann, Lars, Walden, Helen, Shaw, Gary S
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276879/
https://ncbi.nlm.nih.gov/pubmed/30446597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100014
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