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Impact of Autosomal Recessive Juvenile Parkinson’s Disease Mutations on the Structure and Interactions of the Parkin Ubiquitin-like Domain

[Image: see text] Autosomal recessive juvenile parkinsonism (ARJP) is an early onset familial form of Parkinson’s disease. Approximately 50% of all ARJP cases are attributed to mutations in the gene park2, coding for the protein parkin. Parkin is a multidomain E3 ubiquitin ligase with six distinct d...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Safadi, Susan S., Barber, Kathryn R., Shaw, Gary S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2011
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065874/
https://ncbi.nlm.nih.gov/pubmed/21348451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200065g
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