Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson’s disease

Mutations of the ubiquitin ligase parkin account for most autosomal recessive forms of juvenile Parkinson’s disease (AR-JP). Several studies have suggested that parkin possesses DNA-binding and transcriptional activity. We report here that parkin is a p53 transcriptional repressor. First, parkin pre...

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Main Authors: da Costa, Cristine Alves, Sunyach, Claire, Giaime, Emilie, West, Andrew, Corti, Olga, Brice, Alexis, Safe, Stephen, Abou-Sleiman, Patrick M., Wood, Nicholas W., Takahashi, Hitoshi, Goldberg, Mathew S., Shen, Jie, Checler, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952934/
https://ncbi.nlm.nih.gov/pubmed/19801972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1981
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