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Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson’s disease

Mutations of the ubiquitin ligase parkin account for most autosomal recessive forms of juvenile Parkinson’s disease (AR-JP). Several studies have suggested that parkin possesses DNA-binding and transcriptional activity. We report here that parkin is a p53 transcriptional repressor. First, parkin pre...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: da Costa, Cristine Alves, Sunyach, Claire, Giaime, Emilie, West, Andrew, Corti, Olga, Brice, Alexis, Safe, Stephen, Abou-Sleiman, Patrick M., Wood, Nicholas W., Takahashi, Hitoshi, Goldberg, Mathew S., Shen, Jie, Checler, Frédéric
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2009
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952934/
https://ncbi.nlm.nih.gov/pubmed/19801972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1981
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