ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1

Parkin and DJ-1 are two multi-functional proteins linked to autosomal recessive early-onset Parkinson's disease (PD) that have been shown to functionally interact by as-yet-unknown mechanisms. We have delineated the mechanisms by which parkin controls DJ-1. Parkin modulates DJ-1 transcription a...

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Publicado en:J Cell Sci
Autores principales: Duplan, Eric, Giaime, Emilie, Viotti, Julien, Sévalle, Jean, Corti, Olga, Brice, Alexis, Ariga, Hiroyoshi, Qi, Ling, Checler, Frédéric, Alves da Costa, Cristine
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518232/
https://ncbi.nlm.nih.gov/pubmed/23447676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.127340
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