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Structure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease

Mutations in Parkin are one of the predominant hereditary factors found in patients suffering from autosomal recessive juvenile Parkinsonism. Parkin is a member of the E3 ubiquitin ligase family that is defined by a tripartite RING1-in-between-ring (IBR)-RING2 motif. In Parkin, the IBR domain has be...

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Bibliografiske detaljer
Main Authors: Beasley, Steven A., Hristova, Ventzislava A., Shaw, Gary S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805599/
https://ncbi.nlm.nih.gov/pubmed/17360614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610548104
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