Characterization of Silvestrol Pharmacokinetics in Mice Using Liquid Chromatography–Tandem Mass Spectrometry

A sensitive and specific liquid chromatography–tandem mass spectrometry method was developed and validated for the quantification of the plant natural product silvestrol in mice, using ansamitocin P-3 as the internal standard. The method was validated in plasma with a lower limit of quantification o...

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Detalhes bibliográficos
Main Authors: Saradhi, U. V. R. Vijaya, Gupta, Sneha V., Chiu, Ming, Wang, Jiang, Ling, Yonghua, Liu, Zhongfa, Newman, David J., Covey, Joseph M., Kinghorn, A. Douglas, Marcucci, Guido, Lucas, David M., Grever, Michael R., Phelps, Mitch A., Chan, Kenneth K.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160157/
https://ncbi.nlm.nih.gov/pubmed/21499689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-011-9273-x
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