A Sensitive and Specific Liquid Chromatography/Tandem Mass Spectrometry Method for Quantification of Nevirapine and Its Five Metabolites and Their Pharmacokinetics in Baboons

A highly sensitive and specific LC-MS/MS assay was developed and validated to quantify nevirapine (NVP) and its five metabolites (2-, 3-, 8-, 12-hydroxyl NVP [OHNVP] and 4-carboxyl NVP [CANVP]) simultaneously in baboon serum and the assay was used to characterize their pharmacokinetic studies of an...

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Bibliografiske detaljer
Main Authors: Ren, Chen, Fan-Havard, Patty, Schlabritz-Loutsevitch, Natalia, Ling, Yonghua, Chan, Kenneth K., Liu, Zhongfa
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118614/
https://ncbi.nlm.nih.gov/pubmed/19882749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bmc.1353
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