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A Sensitive and Specific Liquid Chromatography/Tandem Mass Spectrometry Method for Quantification of Nevirapine and Its Five Metabolites and Their Pharmacokinetics in Baboons

A highly sensitive and specific LC-MS/MS assay was developed and validated to quantify nevirapine (NVP) and its five metabolites (2-, 3-, 8-, 12-hydroxyl NVP [OHNVP] and 4-carboxyl NVP [CANVP]) simultaneously in baboon serum and the assay was used to characterize their pharmacokinetic studies of an...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ren, Chen, Fan-Havard, Patty, Schlabritz-Loutsevitch, Natalia, Ling, Yonghua, Chan, Kenneth K., Liu, Zhongfa
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2010
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118614/
https://ncbi.nlm.nih.gov/pubmed/19882749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bmc.1353
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