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A Sensitive and Specific Liquid Chromatography/Tandem Mass Spectrometry Method for Quantification of Nevirapine and Its Five Metabolites and Their Pharmacokinetics in Baboons
A highly sensitive and specific LC-MS/MS assay was developed and validated to quantify nevirapine (NVP) and its five metabolites (2-, 3-, 8-, 12-hydroxyl NVP [OHNVP] and 4-carboxyl NVP [CANVP]) simultaneously in baboon serum and the assay was used to characterize their pharmacokinetic studies of an...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3118614/ https://ncbi.nlm.nih.gov/pubmed/19882749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bmc.1353 |
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