Osteoprotegerin Prevents Glucocorticoid-Induced Osteocyte Apoptosis in Mice

The adverse skeletal effects of glucocorticoid excess are due to increased osteoclast survival, decreased production of osteoblasts, and increased apoptosis of osteoblasts and osteocytes, but it remains unknown which of these is the principle cause of the decrease in bone strength. Previous studies...

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Bibliographic Details
Main Authors: Weinstein, Robert S., O'Brien, Charles A., Almeida, Maria, Zhao, Haibo, Roberson, Paula K., Jilka, Robert L., Manolagas, Stavros C.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2011
Subjects:
Calcium-Regulating Hormones
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159783/
https://ncbi.nlm.nih.gov/pubmed/21771887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-0170
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