Cardiac Gene Transfer of Short Hairpin RNA Directed Against Phospholamban Effectively Knocks Down Gene Expression but Causes Cellular Toxicity in Canines

Derangements in calcium cycling have been described in failing hearts, and preclinical studies have suggested that therapies aimed at correcting this defect can lead to improvements in cardiac function and survival. One strategy to improve calcium cycling would be to inhibit phospholamban (PLB), the...

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Detalhes bibliográficos
Main Authors: Bish, Lawrence T., Sleeper, Meg M., Reynolds, Caryn, Gazzara, Jeffrey, Withnall, Elanor, Singletary, Gretchen E., Buchlis, George, Hui, Daniel, High, Katherine A., Gao, Guangping, Wilson, James M., Sweeney, H. Lee
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2011
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159526/
https://ncbi.nlm.nih.gov/pubmed/21542669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2011.035
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