Cardiac Gene Transfer of Short Hairpin RNA Directed Against Phospholamban Effectively Knocks Down Gene Expression but Causes Cellular Toxicity in Canines

Derangements in calcium cycling have been described in failing hearts, and preclinical studies have suggested that therapies aimed at correcting this defect can lead to improvements in cardiac function and survival. One strategy to improve calcium cycling would be to inhibit phospholamban (PLB), the...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bish, Lawrence T., Sleeper, Meg M., Reynolds, Caryn, Gazzara, Jeffrey, Withnall, Elanor, Singletary, Gretchen E., Buchlis, George, Hui, Daniel, High, Katherine A., Gao, Guangping, Wilson, James M., Sweeney, H. Lee
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Mary Ann Liebert, Inc. 2011
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159526/
https://ncbi.nlm.nih.gov/pubmed/21542669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2011.035
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