Cardiac Gene Transfer of Short Hairpin RNA Directed Against Phospholamban Effectively Knocks Down Gene Expression but Causes Cellular Toxicity in Canines

Derangements in calcium cycling have been described in failing hearts, and preclinical studies have suggested that therapies aimed at correcting this defect can lead to improvements in cardiac function and survival. One strategy to improve calcium cycling would be to inhibit phospholamban (PLB), the...

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Detaylı Bibliyografya
Asıl Yazarlar: Bish, Lawrence T., Sleeper, Meg M., Reynolds, Caryn, Gazzara, Jeffrey, Withnall, Elanor, Singletary, Gretchen E., Buchlis, George, Hui, Daniel, High, Katherine A., Gao, Guangping, Wilson, James M., Sweeney, H. Lee
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Mary Ann Liebert, Inc. 2011
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Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159526/
https://ncbi.nlm.nih.gov/pubmed/21542669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2011.035
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