Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling

SET domain containing 6 (SETD6) monomethylates the RelA subunit of nuclear factor kappa B (NF-κB). The ankyrin repeats of G9a-like protein (GLP) recognizes RelA monomethylated at Lys310. Adjacent to Lys310 is Ser311, a known phosphorylation site of RelA. Ser311 phosphorylation inhibits Lys310 methyl...

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Main Authors: Chang, Yanqi, Levy, Dan, Horton, John R., Peng, Junmin, Zhang, Xing, Gozani, Or, Cheng, Xiaodong
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Gene Regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159447/
https://ncbi.nlm.nih.gov/pubmed/21515635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr256
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