Structural basis for the target specificity of actin histidine methyltransferase SETD3

SETD3 is an actin histidine-N(3) methyltransferase, whereas other characterized SET-domain enzymes are protein lysine methyltransferases. We report that in a pre-reactive complex SETD3 binds the N(3)-protonated form (N(3)-H) of actin His73, and in a post-reactive product complex, SETD3 generates the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Dai, Shaobo, Horton, John R., Woodcock, Clayton B., Wilkinson, Alex W., Zhang, Xing, Gozani, Or, Cheng, Xiaodong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684798/
https://ncbi.nlm.nih.gov/pubmed/31388018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11554-6
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