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Structural basis for the target specificity of actin histidine methyltransferase SETD3
SETD3 is an actin histidine-N(3) methyltransferase, whereas other characterized SET-domain enzymes are protein lysine methyltransferases. We report that in a pre-reactive complex SETD3 binds the N(3)-protonated form (N(3)-H) of actin His73, and in a post-reactive product complex, SETD3 generates the...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6684798/ https://ncbi.nlm.nih.gov/pubmed/31388018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11554-6 |
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