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An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation

Most characterized SET domain (SETD) proteins are protein lysine methyltransferases, but SETD3 was recently demonstrated to be a protein (i.e. actin) histidine-N(3) methyltransferase. Human SETD3 shares a high structural homology with two known protein lysine methyltransferases—human SETD6 and the p...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Dai, Shaobo, Horton, John R., Wilkinson, Alex W., Gozani, Or, Zhang, Xing, Cheng, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049955/
https://ncbi.nlm.nih.gov/pubmed/31911441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012319
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