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An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation
Most characterized SET domain (SETD) proteins are protein lysine methyltransferases, but SETD3 was recently demonstrated to be a protein (i.e. actin) histidine-N(3) methyltransferase. Human SETD3 shares a high structural homology with two known protein lysine methyltransferases—human SETD6 and the p...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7049955/ https://ncbi.nlm.nih.gov/pubmed/31911441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012319 |
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