Structural basis for Klf4 recognition of methylated DNA

Transcription factor Krüppel-like factor 4 (Klf4), one of the factors directing cellular reprogramming, recognizes the CpG dinucleotide (whether methylated or unmodified) within a specific G/C-rich sequence. The binding affinity of the mouse Klf4 DNA-binding domain for methylated DNA is only slightl...

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Autores principales: Liu, Yiwei, Olanrewaju, Yusuf Olatunde, Zheng, Yu, Hashimoto, Hideharu, Blumenthal, Robert M., Zhang, Xing, Cheng, Xiaodong
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005678/
https://ncbi.nlm.nih.gov/pubmed/24520114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku134
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