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Distinctive Klf4 mutants determine preference for DNA methylation status

Reprogramming of mammalian genome methylation is critically important but poorly understood. Klf4, a transcription factor directing reprogramming, contains a DNA binding domain with three consecutive C2H2 zinc fingers. Klf4 recognizes CpG or TpG within a specific sequence. Mouse Klf4 DNA binding dom...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Hashimoto, Hideharu, Wang, Dongxue, Steves, Alyse N., Jin, Peng, Blumenthal, Robert M., Zhang, Xing, Cheng, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137437/
https://ncbi.nlm.nih.gov/pubmed/27596594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw774
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