SETD6 lysine methylation of RelA couples GLP activity at chromatin to tonic repression of NF-κB signaling

Protein lysine methylation signaling is implicated in diverse biological and disease processes. Yet the catalytic activity and substrate specificity are unknown for many human protein lysine methyltransferases (PKMTs). We screened over forty candidate PKMTs and identified SETD6 as a methyltransferas...

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Main Authors: Levy, Dan, Kuo, Alex J., Chang, Yanqi, Schaefer, Uwe, Kitson, Christopher, Cheung, Peggie, Espejo, Alexsandra, Zee, Barry M., Liu, Chih Long, Tangsombatvisit, Stephanie, Tennen, Ruth I., Kuo, Andrew Y., Tanjing, Song, Cheung, Regina, Chua, Katrin F., Utz, Paul J., Shi, Xiaobing, Prinjha, Rab K., Lee, Kevin, Garcia, Benjamin A., Bedford, Mark T., Tarakhovsky, Alexander, Cheng, Xiaodong, Gozani, Or
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074206/
https://ncbi.nlm.nih.gov/pubmed/21131967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1968
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