Evidence That Gene Activation and Silencing during Stem Cell Differentiation Requires a Transcriptionally Paused Intermediate State

A surprising portion of both mammalian and Drosophila genomes are transcriptionally paused, undergoing initiation without elongation. We tested the hypothesis that transcriptional pausing is an obligate transition state between definitive activation and silencing as human embryonic stem cells (hESCs...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Golob, Jonathan L., Kumar, Roshan M., Guenther, Matthew G., Pabon, Lil M., Pratt, Gabriel A., Loring, Jeanne F., Laurent, Louise C., Young, Richard A., Murry, Charles E.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2011
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158746/
https://ncbi.nlm.nih.gov/pubmed/21886766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022416
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