Evidence That Gene Activation and Silencing during Stem Cell Differentiation Requires a Transcriptionally Paused Intermediate State

A surprising portion of both mammalian and Drosophila genomes are transcriptionally paused, undergoing initiation without elongation. We tested the hypothesis that transcriptional pausing is an obligate transition state between definitive activation and silencing as human embryonic stem cells (hESCs...

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Detalhes bibliográficos
Main Authors: Golob, Jonathan L., Kumar, Roshan M., Guenther, Matthew G., Pabon, Lil M., Pratt, Gabriel A., Loring, Jeanne F., Laurent, Louise C., Young, Richard A., Murry, Charles E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158746/
https://ncbi.nlm.nih.gov/pubmed/21886766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022416
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