Phase I Pharmacokinetic and Pharmacodynamic Study of the Multikinase Inhibitor Sorafenib in Combination With Clofarabine and Cytarabine in Pediatric Relapsed/Refractory Leukemia

PURPOSE: To assess the toxicity, pharmacokinetics, and pharmacodynamics of multikinase inhibitor sorafenib in combination with clofarabine and cytarabine in children with relapsed/refractory leukemia. PATIENTS AND METHODS: Twelve patients with acute leukemia (11 with acute myeloid leukemia [AML]) re...

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Detalhes bibliográficos
Main Authors: Inaba, Hiroto, Rubnitz, Jeffrey E., Coustan-Smith, Elaine, Li, Lie, Furmanski, Brian D., Mascara, Gerard P., Heym, Kenneth M., Christensen, Robbin, Onciu, Mihaela, Shurtleff, Sheila A., Pounds, Stanley B., Pui, Ching-Hon, Ribeiro, Raul C., Campana, Dario, Baker, Sharyn D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2011
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158600/
https://ncbi.nlm.nih.gov/pubmed/21768474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2011.34.7427
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