Clofarabine Can Replace Anthracyclines and Etoposide in Remission Induction Therapy for Childhood Acute Myeloid Leukemia: The AML08 Multicenter, Randomized Phase III Trial

PURPOSE: To identify effective and less toxic therapy for children with acute myeloid leukemia, we introduced clofarabine into the first course of remission induction to reduce exposure to daunorubicin and etoposide. PATIENTS AND METHODS: From 2008 through 2017, 285 patients were enrolled at eight c...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Rubnitz, Jeffrey E., Lacayo, Norman J., Inaba, Hiroto, Heym, Kenneth, Ribeiro, Raul C., Taub, Jeffrey, McNeer, Jennifer, Degar, Barbara, Schiff, Deborah, Yeoh, Allen Eng-Juh, Coustan-Smith, Elaine, Wang, Lei, Triplett, Brandon, Raimondi, Susana C., Klco, Jeffery, Choi, John, Pounds, Stanley, Pui, Ching-Hon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2019
Assuntos:
ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001777/
https://ncbi.nlm.nih.gov/pubmed/31246522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.19.00327
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