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Sorafenib population pharmacokinetics and skin toxicities in children and adolescents with refractory/relapsed leukemia or solid tumor malignancies

PURPOSE: To determine the pharmacokinetics and skin toxicity profile of sorafenib in children with refractory/relapsed malignancies. EXPERIMENTAL DESIGN: Sorafenib was administered concurrently or sequentially with clofarabine and cytarabine (Clo/AraC) to leukemia patients or with bevacizumab and cy...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Inaba, Hiroto, Panetta, John C., Pounds, Stanley B., Wang, Lei, Li, Lie, Navid, Fariba, Federico, Sara M., Eisenmann, Eric D., Vasilyeva, Aksana, Wang, Yong-Dong, Shurtleff, Sheila, Pui, Ching-Hon, Gruber, Tanja A., Ribeiro, Raul C., Rubnitz, Jeffrey E., Baker, Sharyn D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911639/
https://ncbi.nlm.nih.gov/pubmed/31455680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0470
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