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Peloruside- and Laulimalide-Resistant Human Ovarian Carcinoma Cells Have βI-Tubulin Mutations and Altered Expression of βII- and βIII-Tubulin Isotypes

Peloruside A and laulimalide are potent microtubule-stabilizing natural products with a mechanism of action similar to that of paclitaxel. However, the binding site of peloruside A and laulimalide on tubulin remains poorly understood. Drug resistance in anticancer treatment is a serious problem. We...

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Bibliografiset tiedot
Päätekijät: Kanakkanthara, Arun, Wilmes, Anja, O'Brate, Aurora, Escuin, Daniel, Chan, Ariane, Gjyrezi, Ada, Crawford, Janet, Rawson, Pisana, Kivell, Bronwyn, Northcote, Peter T., Hamel, Ernest, Giannakakou, Paraskevi, Miller, John H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158586/
https://ncbi.nlm.nih.gov/pubmed/21653684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-1057
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