The Synergistic Combination of the Farnesyl Transferase Inhibitor Lonafarnib and Paclitaxel Enhances Tubulin Acetylation and Requires a Functional Tubulin Deacetylase

Farnesyl transferase (FT) inhibitors (FTI) are anticancer agents developed to target oncogenic Ras proteins by inhibiting Ras farnesylation. FTIs potently synergize with paclitaxel and other microtubule-stabilizing drugs; however, the mechanistic basis underlying this synergistic interaction remains...

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Detalhes bibliográficos
Main Authors: Marcus, Adam I., Zhou, Jun, O’Brate, Aurora, Hamel, Ernest, Wong, Jason, Nivens, Michael, El-Naggar, Adel, Yao, Tso-Pang, Khuri, Fadlo R., Giannakakou, Paraskevi
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1861827/
https://ncbi.nlm.nih.gov/pubmed/15867388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-04-3757
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