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Microtubule disruption targets HIF-1α mRNA to cytoplasmic P-bodies for translational repression
The hypoxia inducible factor 1α (HIF-1α) is overexpressed in solid tumors, driving tumor angiogenesis and survival. However, the mechanisms regulating HIF-1α expression in solid tumors are not fully understood. In this study, we find that microtubule integrity and dynamics are intricately involved i...
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| Asıl Yazarlar: | , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The Rockefeller University Press
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3019555/ https://ncbi.nlm.nih.gov/pubmed/21220510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201004145 |
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