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Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics

The tumor suppressor protein p53 localizes to microtubules (MT) and, in response to DNA damage, is transported to the nucleus via the MT minus-end-directed motor protein dynein. Dynein is also responsible for MT-mediated nuclear targeting of adenovirus type 2 (Ad2). Here we show that treatment with...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Giannakakou, Paraskevi, Nakano, Michel, Nicolaou, Kyriacos C., O'Brate, Aurora, Yu, Jian, Blagosklonny, Mikhail V., Greber, Urs F., Fojo, Tito
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125062/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12145320/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.132275599
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