Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics

The tumor suppressor protein p53 localizes to microtubules (MT) and, in response to DNA damage, is transported to the nucleus via the MT minus-end-directed motor protein dynein. Dynein is also responsible for MT-mediated nuclear targeting of adenovirus type 2 (Ad2). Here we show that treatment with...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Giannakakou, Paraskevi, Nakano, Michel, Nicolaou, Kyriacos C., O'Brate, Aurora, Yu, Jian, Blagosklonny, Mikhail V., Greber, Urs F., Fojo, Tito
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2002
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC125062/
https://ncbi.nlm.nih.gov/pubmed/12145320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132275599
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