Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics

The tumor suppressor protein p53 localizes to microtubules (MT) and, in response to DNA damage, is transported to the nucleus via the MT minus-end-directed motor protein dynein. Dynein is also responsible for MT-mediated nuclear targeting of adenovirus type 2 (Ad2). Here we show that treatment with...

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Main Authors: Giannakakou, Paraskevi, Nakano, Michel, Nicolaou, Kyriacos C., O'Brate, Aurora, Yu, Jian, Blagosklonny, Mikhail V., Greber, Urs F., Fojo, Tito
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2002
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC125062/
https://ncbi.nlm.nih.gov/pubmed/12145320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132275599
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