Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics
The tumor suppressor protein p53 localizes to microtubules (MT) and, in response to DNA damage, is transported to the nucleus via the MT minus-end-directed motor protein dynein. Dynein is also responsible for MT-mediated nuclear targeting of adenovirus type 2 (Ad2). Here we show that treatment with...
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| Yayımlandı: | Proc Natl Acad Sci U S A |
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| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2002
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125062/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12145320/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.132275599 |
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