Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1

BACKGROUND: Ire1 is a signal transduction protein in the endoplasmic reticulum (ER) membrane that serves to adjust the protein-folding capacity of the ER according to the needs of the cell. Ire1 signals, in a transcriptional program, the unfolded protein response (UPR) via the coordinated action of...

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Main Authors: Korennykh, Alexei V, Egea, Pascal F, Korostelev, Andrei A, Finer-Moore, Janet, Stroud, Robert M, Zhang, Chao, Shokat, Kevan M, Walter, Peter
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158555/
https://ncbi.nlm.nih.gov/pubmed/21729334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-9-48
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