Structural and functional basis for RNA cleavage by Ire1

BACKGROUND: The unfolded protein response (UPR) controls the protein folding capacity of the endoplasmic reticulum (ER). Central to this signaling pathway is the ER-resident bifunctional transmembrane kinase/endoribonuclease Ire1. The endoribonuclease (RNase) domain of Ire1 initiates a non-conventio...

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Main Authors: Korennykh, Alexei V, Korostelev, Andrei A, Egea, Pascal F, Finer-Moore, Janet, Stroud, Robert M, Zhang, Chao, Shokat, Kevan M, Walter, Peter
格式: Artigo
語言:Inglês
出版: BioMed Central 2011
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149027/
https://ncbi.nlm.nih.gov/pubmed/21729333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-9-47
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