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Structural and functional characterization of a single-chain peptide–MHC molecule that modulates both naive and activated CD8(+) T cells
Peptide–MHC (pMHC) multimers, in addition to being tools for tracking and quantifying antigen-specific T cells, can mediate downstream signaling after T-cell receptor engagement. In the absence of costimulation, this can lead to anergy or apoptosis of cognate T cells, a property that could be exploi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3158197/ https://ncbi.nlm.nih.gov/pubmed/21825122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110971108 |
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