Predominant occupation of the class I MHC molecule H-2K(wm7) with a single self-peptide suggests a mechanism for its diabetes-protective effect

Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell-mediated destruction of insulin-producing pancreatic β cells. In both humans and the non-obese diabetic (NOD) mouse model of T1D, class II MHC alleles are the primary determinant of disease susceptibility. However, class I MHC ge...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Brims, Daniel R., Qian, Jie, Jarchum, Irene, Mikesh, Leann, Palmieri, Edith, Ramagopal, Udupi A., Malashkevich, Vladimir N., Chaparro, Rodolfo J., Lund, Torben, Hattori, Masakazu, Shabanowitz, Jeffrey, Hunt, Donald F., Nathenson, Stanley G., Almo, Steven C., DiLorenzo, Teresa P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2010
Konular:
Original Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829095/
https://ncbi.nlm.nih.gov/pubmed/20093428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxp127
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller