Predominant occupation of the class I MHC molecule H-2K(wm7) with a single self-peptide suggests a mechanism for its diabetes-protective effect

Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell-mediated destruction of insulin-producing pancreatic β cells. In both humans and the non-obese diabetic (NOD) mouse model of T1D, class II MHC alleles are the primary determinant of disease susceptibility. However, class I MHC ge...

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Autori principali: Brims, Daniel R., Qian, Jie, Jarchum, Irene, Mikesh, Leann, Palmieri, Edith, Ramagopal, Udupi A., Malashkevich, Vladimir N., Chaparro, Rodolfo J., Lund, Torben, Hattori, Masakazu, Shabanowitz, Jeffrey, Hunt, Donald F., Nathenson, Stanley G., Almo, Steven C., DiLorenzo, Teresa P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2010
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Original Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829095/
https://ncbi.nlm.nih.gov/pubmed/20093428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxp127
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