Phase I/II Study of Trastuzumab in Combination With Everolimus (RAD001) in Patients With HER2-Overexpressing Metastatic Breast Cancer Who Progressed on Trastuzumab-Based Therapy

PURPOSE: Trastuzumab resistance has been linked to activation of the phosphoinositol 3-kinase (PI3K) pathway. Phosphatase and tensin homolog (PTEN) is a dual phosphatase that counteracts the PI3K function; PTEN loss leads to activation of the Akt cascade and the downstream mammalian target of rapamy...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Morrow, Phuong K., Wulf, Gerburg M., Ensor, Joe, Booser, Daniel J., Moore, Julia A., Flores, Peter R., Xiong, Yan, Zhang, Siyuan, Krop, Ian E., Winer, Eric P., Kindelberger, David W., Coviello, Jeanna, Sahin, Aysegul A., Nuñez, Rodolfo, Hortobagyi, Gabriel N., Yu, Dihua, Esteva, Francisco J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society of Clinical Oncology 2011
विषय:
Original Reports
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157979/
https://ncbi.nlm.nih.gov/pubmed/21730275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.32.2321
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