PTEN, PIK3CA, p-AKT, and p-p70S6K Status: Association with Trastuzumab Response and Survival in Patients with HER2-Positive Metastatic Breast Cancer

Phosphatase and tensin homolog (PTEN) is a key modulator of trastuzumab sensitivity in HER2-overexpressing breast cancer. Because PTEN opposes the downstream signaling of phosphoinositide 3-kinase (PI3K), we investigated the role of PTEN and other components of the PI3K pathway in trastuzumab resist...

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Detalhes bibliográficos
Main Authors: Esteva, Francisco J., Guo, Hua, Zhang, Siyuan, Santa-Maria, Cesar, Stone, Steven, Lanchbury, Jerry S., Sahin, Aysegul A., Hortobagyi, Gabriel N., Yu, Dihua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947262/
https://ncbi.nlm.nih.gov/pubmed/20813970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090885
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