Phase I/II Study of Trastuzumab in Combination With Everolimus (RAD001) in Patients With HER2-Overexpressing Metastatic Breast Cancer Who Progressed on Trastuzumab-Based Therapy

PURPOSE: Trastuzumab resistance has been linked to activation of the phosphoinositol 3-kinase (PI3K) pathway. Phosphatase and tensin homolog (PTEN) is a dual phosphatase that counteracts the PI3K function; PTEN loss leads to activation of the Akt cascade and the downstream mammalian target of rapamy...

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Detalhes bibliográficos
Main Authors: Morrow, Phuong K., Wulf, Gerburg M., Ensor, Joe, Booser, Daniel J., Moore, Julia A., Flores, Peter R., Xiong, Yan, Zhang, Siyuan, Krop, Ian E., Winer, Eric P., Kindelberger, David W., Coviello, Jeanna, Sahin, Aysegul A., Nuñez, Rodolfo, Hortobagyi, Gabriel N., Yu, Dihua, Esteva, Francisco J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2011
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157979/
https://ncbi.nlm.nih.gov/pubmed/21730275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.32.2321
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