Phase I/II Study of Trastuzumab in Combination With Everolimus (RAD001) in Patients With HER2-Overexpressing Metastatic Breast Cancer Who Progressed on Trastuzumab-Based Therapy

PURPOSE: Trastuzumab resistance has been linked to activation of the phosphoinositol 3-kinase (PI3K) pathway. Phosphatase and tensin homolog (PTEN) is a dual phosphatase that counteracts the PI3K function; PTEN loss leads to activation of the Akt cascade and the downstream mammalian target of rapamy...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Morrow, Phuong K., Wulf, Gerburg M., Ensor, Joe, Booser, Daniel J., Moore, Julia A., Flores, Peter R., Xiong, Yan, Zhang, Siyuan, Krop, Ian E., Winer, Eric P., Kindelberger, David W., Coviello, Jeanna, Sahin, Aysegul A., Nuñez, Rodolfo, Hortobagyi, Gabriel N., Yu, Dihua, Esteva, Francisco J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Clinical Oncology 2011
Témata:
Original Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157979/
https://ncbi.nlm.nih.gov/pubmed/21730275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.32.2321
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky