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PTTG1 Attenuates Drug-Induced Cellular Senescence

As PTTG1 (pituitary tumor transforming gene) abundance correlates with adverse outcomes in cancer treatment, we determined mechanisms underlying this observation by assessing the role of PTTG1 in regulating cell response to anti-neoplastic drugs. HCT116 cells devoid of PTTG1 (PTTG1(−/−)) exhibited e...

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Bibliografische gegevens
Hoofdauteurs: Tong, Yunguang, Zhao, Weijiang, Zhou, Cuiqi, Wawrowsky, Kolja, Melmed, Shlomo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157437/
https://ncbi.nlm.nih.gov/pubmed/21858218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023754
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