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E2F1 Induces Pituitary Tumor Transforming Gene (PTTG1) Expression in Human Pituitary Tumors
Rb/E2F is dysregulated in murine and human pituitary tumors. Pituitary tumor transforming gene (PTTG1), a securin protein, is required for pituitary tumorigenesis, and PTTG1 deletion attenuates pituitary tumor development in Rb(+/−) mice. E2F1 and PTTG1 were concordantly overexpressed in 29 of 46 Rb...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Endocrine Society
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2796149/ https://ncbi.nlm.nih.gov/pubmed/19837943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0161 |
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