Pathogenic Relevance of IgG and IgM Antibodies against Desmoglein 3 in Blister Formation in Pemphigus Vulgaris

Pemphigus vulgaris is an autoimmune disease caused by IgG antibodies against desmoglein 3 (Dsg3). Previously, we isolated a pathogenic mAb against Dsg3, AK23 IgG, which induces a pemphigus vulgaris-like phenotype characterized by blister formation. In the present study, we generated a transgenic mou...

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Hlavní autoři: Tsunoda, Kazuyuki, Ota, Takayuki, Saito, Masataka, Hata, Tsuyoshi, Shimizu, Atsushi, Ishiko, Akira, Yamada, Taketo, Nakagawa, Taneaki, Kowalczyk, Andrew P., Amagai, Masayuki
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2011
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157249/
https://ncbi.nlm.nih.gov/pubmed/21718682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.04.015
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