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Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering()

BACKGROUND: Pemphigus foliaceus (PF) is an autoimmune blistering disease caused by autoantibodies (Abs) against desmoglein 1 (Dsg1). PF sera contain polyclonal Abs which are heterogeneous mixture of both pathogenic and non-pathogenic Abs, as shown by isolation of monoclonal Abs (mAbs). OBJECTIVE: To...

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Bibliografische gegevens
Gepubliceerd in:J Dermatol Sci
Hoofdauteurs: Yoshida, Kenji, Ishii, Ken, Shimizu, Atsushi, Yokouchi, Mariko, Amagai, Masayuki, Shiraishi, Ken, Shirakata, Yuji, Stanley, John R., Ishiko, Akira
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510496/
https://ncbi.nlm.nih.gov/pubmed/28024684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jdermsci.2016.12.010
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