Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope

Fogo Selvagem (FS), the endemic form of pemphigus foliaceus, is mediated by pathogenic IgG4 autoantibodies against the amino-terminal extracellular cadherin domain of the desmosomal cadherin desmoglein 1 (Dsg1). Here we define the detailed epitopes of these pathogenic antibodies. Proteolytic footpri...

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Udgivet i:J Autoimmun
Main Authors: Evangelista, Flor, Roth, Aleeza J, Prisayanh, Phillip, Temple, Brenda R, Li, Ning, Qian, Ye, Culton, Donna A, Liu, Zhi, Harrison, Oliver J., Brasch, Julia, Honig, Barry, Shapiro, Lawrence, Diaz, Luis A
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5902409/
https://ncbi.nlm.nih.gov/pubmed/29307589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2017.12.017
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