Desmoglein 3–specific CD4(+) T cells induce pemphigus vulgaris and interface dermatitis in mice

Pemphigus vulgaris (PV) is a severe autoimmune disease involving blistering of the skin and mucous membranes. It is caused by autoantibodies against desmoglein 3 (Dsg3), an adhesion molecule critical for maintaining epithelial integrity in the skin, oral mucosa, and esophagus. Knowing the antigen ta...

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Hauptverfasser: Takahashi, Hayato, Kouno, Michiyoshi, Nagao, Keisuke, Wada, Naoko, Hata, Tsuyoshi, Nishimoto, Shuhei, Iwakura, Yoichiro, Yoshimura, Akihiko, Yamada, Taketo, Kuwana, Masataka, Fujii, Hideki, Koyasu, Shigeo, Amagai, Masayuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2011
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163963/
https://ncbi.nlm.nih.gov/pubmed/21821914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57379
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