Peptide-mediated desmoglein 3 crosslinking prevents pemphigus vulgaris autoantibody-induced skin blistering

In pemphigus vulgaris, a life-threatening autoimmune skin disease, epidermal blisters are caused by autoantibodies primarily targeting desmosomal cadherins desmoglein 3 (DSG3) and DSG1, leading to loss of keratinocyte cohesion. Due to limited insights into disease pathogenesis, current therapy relie...

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Detalhes bibliográficos
Main Authors: Spindler, Volker, Rötzer, Vera, Dehner, Carina, Kempf, Bettina, Gliem, Martin, Radeva, Mariya, Hartlieb, Eva, Harms, Gregory S., Schmidt, Enno, Waschke, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561799/
https://ncbi.nlm.nih.gov/pubmed/23298835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60139
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