The Extent of Desmoglein 3 Depletion in Pemphigus Vulgaris Is Dependent on Ca(2+)-Induced Differentiation: A Role in Suprabasal Epidermal Skin Splitting?

Pemphigus vulgaris (PV) is an autoimmune disease of the skin and mucous membranes and is characterized by development of autoantibodies against the desmosomal cadherins desmoglein (Dsg) 3 and Dsg1 and formation of intraepidermal suprabasal blisters. Depletion of Dsg3 is a critical mechanism in PV pa...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Spindler, Volker, Endlich, Alexander, Hartlieb, Eva, Vielmuth, Franziska, Schmidt, Enno, Waschke, Jens
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Investigative Pathology 2011
Ämnen:
Regular Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181381/
https://ncbi.nlm.nih.gov/pubmed/21864491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.06.043
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