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The Extent of Desmoglein 3 Depletion in Pemphigus Vulgaris Is Dependent on Ca(2+)-Induced Differentiation: A Role in Suprabasal Epidermal Skin Splitting?

Pemphigus vulgaris (PV) is an autoimmune disease of the skin and mucous membranes and is characterized by development of autoantibodies against the desmosomal cadherins desmoglein (Dsg) 3 and Dsg1 and formation of intraepidermal suprabasal blisters. Depletion of Dsg3 is a critical mechanism in PV pa...

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Bibliografske podrobnosti
Main Authors: Spindler, Volker, Endlich, Alexander, Hartlieb, Eva, Vielmuth, Franziska, Schmidt, Enno, Waschke, Jens
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181381/
https://ncbi.nlm.nih.gov/pubmed/21864491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.06.043
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