Orally Administered Prion Protein Is Incorporated by M Cells and Spreads into Lymphoid Tissues with Macrophages in Prion Protein Knockout Mice

Transmissible spongiform encephalopathies are fatal neurodegenerative diseases. Infection by the oral route is assumed to be important, although its pathogenesis is not understood. Using prion protein (PrP) knockout mice, we investigated the sequence of events during the invasion of orally administe...

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Hlavní autoři: Takakura, Ikuro, Miyazawa, Kohtaro, Kanaya, Takashi, Itani, Wataru, Watanabe, Kouichi, Ohwada, Shyuichi, Watanabe, Hitoshi, Hondo, Tetsuya, Rose, Michael T., Mori, Tsuyoshi, Sakaguchi, Suehiro, Nishida, Noriyuki, Katamine, Shigeru, Yamaguchi, Takahiro, Aso, Hisashi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2011
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157171/
https://ncbi.nlm.nih.gov/pubmed/21763679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.05.058
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