Orally Administered Prion Protein Is Incorporated by M Cells and Spreads into Lymphoid Tissues with Macrophages in Prion Protein Knockout Mice

Transmissible spongiform encephalopathies are fatal neurodegenerative diseases. Infection by the oral route is assumed to be important, although its pathogenesis is not understood. Using prion protein (PrP) knockout mice, we investigated the sequence of events during the invasion of orally administe...

Full description

Saved in:
Bibliographic Details
Main Authors: Takakura, Ikuro, Miyazawa, Kohtaro, Kanaya, Takashi, Itani, Wataru, Watanabe, Kouichi, Ohwada, Shyuichi, Watanabe, Hitoshi, Hondo, Tetsuya, Rose, Michael T., Mori, Tsuyoshi, Sakaguchi, Suehiro, Nishida, Noriyuki, Katamine, Shigeru, Yamaguchi, Takahiro, Aso, Hisashi
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2011
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157171/
https://ncbi.nlm.nih.gov/pubmed/21763679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.05.058
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items