Native low density lipoprotein induces pancreatic β cell apoptosis through generating excess reactive oxygen species

BACKGROUND: The growing evidences demonstrated hyperlipidemia in obesity and type 2 diabetes is characterized by high levels of free fatty acids, low-density lipoprotein (LDL), triglyceride, and cholesterol. METHOD AND RESULTS: We investigated the effect of LDL particles (LDLs) loading on MIN6 cells...

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Detalhes bibliográficos
Main Authors: Lu, Xiuli, Liu, Jianli, Cao, Xiangyu, Hou, Xiao, Wang, Xude, Zhao, Chenguang, Wang, Youliang, Li, Yang, Seo, Hisao, Gao, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156751/
https://ncbi.nlm.nih.gov/pubmed/21791078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-511X-10-123
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