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Interference between PARPs and SIRT1: a novel approach to healthy ageing?

Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators.

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Sonraí Bibleagrafaíochta
Main Authors: CantÓ, Carles, Auwerx, Johan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156604/
https://ncbi.nlm.nih.gov/pubmed/21566260
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